While there exists some registry hack I found online I feel the best method to configure a custom MTU was not in the driver (or registry), but rather by using the command line utility netsh.
You will first need to figure out the index number of your nic with the command netsh interface ipv4 show interfaces
After finding the index number you will need to use it in the next command netsh interface ipv4 set subinterface "16" mtu=1340 store=persistent
Disclaimer: The size of 1340 is used as an example here.